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연구성과
학술발표
본문
The biotic-elicitor on Damnacanthus major Calli promotes wound healing by accelerating the migration of the HaCaT cells
- 작성자
- 관리자
- 작성일
- 2024-11-26 09:00:48
- 조회수
- 3097
- 첨부파일
○ 발표제목 : The biotic-elicitor on Damnacanthus major Calli promotes wound healing by accelerating the migration of the HaCaT cells.
○ 발표자 : Jin Hwang, Eun Bi Jang, Mi-ye Kwon, So-yeon Oh, Ho Bong Hyun, Boram Go, Jong-Du Lee, Weon-Jong Yoon, Young-min Ham, Ji gwon Park*
○ 학술대회명 : MSK2024 한국미생물학회 국제학술대회
○ 발표일자 및 장소 : 2024-10-30 (수) ~ 2024-11-01 (금) / 제주국제컨벤션센터
○ 초록
Wound healing is a vital issue influencing quality of life, and the need for products associated with wound healing is growing annually. New materials and therapies for skin wounds are researched continuously and developed to increase treatment efficacy. In the present study, the effect of the biotic elicitor on D. major Calli (DMCB) was investigated in cutaneous wound healing in in vitro. Biotic elicitors are substances of biological origin, such as microorganisms and polysaccharides found in plant cell walls. To select the bacteria for biotic elicitor, we tested the adapted well to the plant medium for co-culture with D. major calli (DMC). Bacillus subtilis from Rubus illecebrosus flower was increased by elicitor treatment for proliferation and browning of callus in D. major more than the non-treated group. Additionally, we observed that DMCB demonstrates efficacy in wound healing by a scratch assay using HaCaT cells and human dermal fibroblasts(HDF). Moreover, DMCB promotes skin moisturizing effects for skin function-related components like hyaluronic acid. These results suggest that DMCB can be an effective therapeutic agent by promoting keratinocytes and fibroblasts and enhancing overall skin function.
○ 발표자 : Jin Hwang, Eun Bi Jang, Mi-ye Kwon, So-yeon Oh, Ho Bong Hyun, Boram Go, Jong-Du Lee, Weon-Jong Yoon, Young-min Ham, Ji gwon Park*
○ 학술대회명 : MSK2024 한국미생물학회 국제학술대회
○ 발표일자 및 장소 : 2024-10-30 (수) ~ 2024-11-01 (금) / 제주국제컨벤션센터
○ 초록
Wound healing is a vital issue influencing quality of life, and the need for products associated with wound healing is growing annually. New materials and therapies for skin wounds are researched continuously and developed to increase treatment efficacy. In the present study, the effect of the biotic elicitor on D. major Calli (DMCB) was investigated in cutaneous wound healing in in vitro. Biotic elicitors are substances of biological origin, such as microorganisms and polysaccharides found in plant cell walls. To select the bacteria for biotic elicitor, we tested the adapted well to the plant medium for co-culture with D. major calli (DMC). Bacillus subtilis from Rubus illecebrosus flower was increased by elicitor treatment for proliferation and browning of callus in D. major more than the non-treated group. Additionally, we observed that DMCB demonstrates efficacy in wound healing by a scratch assay using HaCaT cells and human dermal fibroblasts(HDF). Moreover, DMCB promotes skin moisturizing effects for skin function-related components like hyaluronic acid. These results suggest that DMCB can be an effective therapeutic agent by promoting keratinocytes and fibroblasts and enhancing overall skin function.