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Contents
연구성과
학술발표
본문
Effects of Schiz ophragma hydrangeoides Leaves on Anti-oxidant and Anti-wrinkle
- 작성자
- 관리자
- 작성일
- 2024-02-19 09:55:44.0
- 조회수
- 112
- 첨부파일
○ 발표제목
Effects of Schiz ophragma hydrangeoides Leaves on Anti-oxidant and Anti-wrinkle.
○ 발표자
So Yeon Oh†, Sung Chun Kim, Ho Bong Hyun, Boram Go, Hyejin Hyeon, Yong-Hwan Jung, and Young-Min Ham††
○ 학술대회명
2022년 대한화장품학회 춘계학술발표대회
○ 발표일자 및 장소
2022. 5. 20. The-K호텔 서울호텔
○ 초록
Schizophragma hydrangeoides (S. hydrangeoides) is a vine that grows attached to the foothills or rock surfaces of Jeju and Ulleungdo. This study confirmed the anti-oxidant activity and anti-wrinkle effects of 70% ethanol (EtOH) extract and solvent fractions of S. hydrangeoides leaves. Additionally, we found the major active compounds of butanol (BuOH) fraction, and investigated anti-wrinkle effect of the isolated compounds. The results showed that BuOH and ethyl acetate (EA) fractions have more contain total polyphenols and flavonoids than extracts. BuOH and EA fractions showed the good activities in DPPH and ABTS radical scavenging activity. Moreover, BuOH fraction showed the best inhibition of MMP-1 production without cytotoxicity in UVA irradiated-HDFn cells. To isolate the active ingredient, BuOH fraction was further purified to obtain four phytochemicals: neochlorogenic acid (1), quercetin-3-glucosyl-(1-2)-rhamnoside (2), quercetin-3-xylosyl-(1-2)-rhamnoside (3), quercitrin (4). Among the compounds isolated from BuOH, quercetin-3-glucosyl-(1-2)-rhamnoside (2) was identified as the main compound. As a result of confirming the MMP-1 inhibition rate of compound (1) ∼ (4), quercetin-3-glucosyl-(1-2)-rhamnoside (2) inhibited the expressions of MMP-1 production without cytotoxicity. Based on these research results, we suggest that the possibility of developing a natural antioxidant and anti-wrinkle functional cosmetic material of S. hydrangeoides.
Effects of Schiz ophragma hydrangeoides Leaves on Anti-oxidant and Anti-wrinkle.
○ 발표자
So Yeon Oh†, Sung Chun Kim, Ho Bong Hyun, Boram Go, Hyejin Hyeon, Yong-Hwan Jung, and Young-Min Ham††
○ 학술대회명
2022년 대한화장품학회 춘계학술발표대회
○ 발표일자 및 장소
2022. 5. 20. The-K호텔 서울호텔
○ 초록
Schizophragma hydrangeoides (S. hydrangeoides) is a vine that grows attached to the foothills or rock surfaces of Jeju and Ulleungdo. This study confirmed the anti-oxidant activity and anti-wrinkle effects of 70% ethanol (EtOH) extract and solvent fractions of S. hydrangeoides leaves. Additionally, we found the major active compounds of butanol (BuOH) fraction, and investigated anti-wrinkle effect of the isolated compounds. The results showed that BuOH and ethyl acetate (EA) fractions have more contain total polyphenols and flavonoids than extracts. BuOH and EA fractions showed the good activities in DPPH and ABTS radical scavenging activity. Moreover, BuOH fraction showed the best inhibition of MMP-1 production without cytotoxicity in UVA irradiated-HDFn cells. To isolate the active ingredient, BuOH fraction was further purified to obtain four phytochemicals: neochlorogenic acid (1), quercetin-3-glucosyl-(1-2)-rhamnoside (2), quercetin-3-xylosyl-(1-2)-rhamnoside (3), quercitrin (4). Among the compounds isolated from BuOH, quercetin-3-glucosyl-(1-2)-rhamnoside (2) was identified as the main compound. As a result of confirming the MMP-1 inhibition rate of compound (1) ∼ (4), quercetin-3-glucosyl-(1-2)-rhamnoside (2) inhibited the expressions of MMP-1 production without cytotoxicity. Based on these research results, we suggest that the possibility of developing a natural antioxidant and anti-wrinkle functional cosmetic material of S. hydrangeoides.