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연구성과
학술발표
본문
Immature persimmon (Diospyros kaki Thunb.) extract suppressed obesity by regulating lipid metabolism in 3T3-L1 cells
- 작성자
- 관리자
- 작성일
- 2023-11-14 10:20:38.0
- 조회수
- 174
- 첨부파일
○ 발표제목: Immature persimmon (Diospyros kaki Thunb.) extract suppressed obesity by regulating lipid metabolism in 3T3-L1 cells
○ 발표자: 윤선아, 고보람, 현호봉, 김성천, 현혜진, 정용환, 함영민
○ 학술대회명: 2023 한국분자세포생물학회 (2023 International Conference Korean Society for Molecular and Cellular Biology)
○ 발표일자 및 장소: 2023. 11. 7 제주국제컨벤션센터
○ 초록
Our previous studies reported that 50% ethanol extract of immature persimmon (Diospyros kaki Thunb.) suppressed body weight gain, adipose tissue weight, and serum triglyceride levels in a high-fat-diet induced mouse model. This study was performed to investigate whether the 50% ethanol extract of Diospyros kaki Thunb. could regulate lipid metabolism by identifying its mechanism in 3T3-L1 cells. As a result, whereas did not influence on cell viability and toxicity, a significant decrease in the accumulation of lipid droplets was observed in a concentration-dependent manner during adipogenesis (adipogenic differentiation). Also, consistent with animal studies, Diospyros kaki Thunb. extract (DKE) dose-dependently suppressed peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins that induce adipocyte differentiation in 3T3-L1 pre-adipocytes. In addition, it increased phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in a dose-dependent manner in 3T3-L1 cells. In conclusion, these results present that immature persimmon (Diospyros kaki Thunb.) may have potential as a natural agent for preventing and/or treating obesity.
○ 발표자: 윤선아, 고보람, 현호봉, 김성천, 현혜진, 정용환, 함영민
○ 학술대회명: 2023 한국분자세포생물학회 (2023 International Conference Korean Society for Molecular and Cellular Biology)
○ 발표일자 및 장소: 2023. 11. 7 제주국제컨벤션센터
○ 초록
Our previous studies reported that 50% ethanol extract of immature persimmon (Diospyros kaki Thunb.) suppressed body weight gain, adipose tissue weight, and serum triglyceride levels in a high-fat-diet induced mouse model. This study was performed to investigate whether the 50% ethanol extract of Diospyros kaki Thunb. could regulate lipid metabolism by identifying its mechanism in 3T3-L1 cells. As a result, whereas did not influence on cell viability and toxicity, a significant decrease in the accumulation of lipid droplets was observed in a concentration-dependent manner during adipogenesis (adipogenic differentiation). Also, consistent with animal studies, Diospyros kaki Thunb. extract (DKE) dose-dependently suppressed peroxisome proliferator-activated receptor γ and CCAAT/enhancer-binding proteins that induce adipocyte differentiation in 3T3-L1 pre-adipocytes. In addition, it increased phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in a dose-dependent manner in 3T3-L1 cells. In conclusion, these results present that immature persimmon (Diospyros kaki Thunb.) may have potential as a natural agent for preventing and/or treating obesity.